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The overall effect of Metformin use for PCOS is lowered testosterone levels, improved ovulation and fertility as well as a more regular menstrual cycle. It is a non-inferior alternative to ethinyl estradiol injection," says Dr Moti Singh, an assistant professor at the Department of Endocrinology and Metabolism at Massachusetts General Hospital and senior faculty member of the Massachusetts Women's Health Initiative.It is well known that metformin is capable of boosting testosterone levels by 50 percent - it was introduced earlier this year to treat high cholesterol in men.With the increased awareness of hypogonadism in women in some parts of the developed world, it is important for healthcare professionals to know that metformin may increase the frequency, severity and duration of hypogonadism in women by as much as 40 percent, is anabolic protein better than whey protein.For the study, published in the Journal of Clinical Endocrinology & Metabolism, researchers tested how long a woman takes to have a normal menstrual cycle when taking Metformin in addition to taking other anti-oxidants. They compared the data from two groups of women: those who started Metformin at 16 weeks of the first trimester and stopped it at 36 weeks of the third trimester and those who took metformin on a daily basis, clomid ovulation calculator.The data showed that the two groups have the same rate of hypogonadism after 18 weeks of treatment. But with metformin, women taking it for 18 weeks of the first trimester showed an 8 percent increase in the frequency of their menstrual cycles compared to the control group which started out taking metformin for the same period, ovulation clomid.When the researchers looked at women who started metformin after 36 weeks' of the first trimester and stopped it at 20 weeks, they found no difference in the rate of hypogonadism between the two groups. They did find an increased chance if the women took metformin for the last 28 weeks of the first trimester, is anabolic steroids legal in usa. While this would be in line with previous studies, it is the first time that they have had such data.It should be noted, however, that it took 12 months after the first treatment to have a normal menstrual cycle in the control group in this study, clomid ovulation. "Since we were looking at a single treatment, we could not rule out the possibility of some other treatments affecting the measurements, and so we did not look into placebo effects," explains Dr Singh.The researchers suggest that it may be related to the estrogenic activity of metformin, is anabolic warfare steroids.